|Alias||Ampelopsin; 27200-12-0; Ampeloptin; (+)-Dihydromyricetin; (+)-Ampelopsin|
Dihydromyricetin(Generally called Ampelopsin or DIM), It is a flavanonol with antioxidant and anti-cancer activity, a type of flavonoid. found to have anti-alcohol intoxication effects. It is found in the Ampelopsis species japonica, megalophylla, and Grossedentata; Cercidiphyllum japonicum; Hovenia Dulcis; Rhododendron Cinnabarinum; some Pinus species; and some Cedrus species, as well as in Salix sachalinensis. Hovenia Dulcis has been used in traditional Japanese, Chinese, and Korean medicines to treat fever, parasitic infection, as a laxative, and treatment of liver diseases, and as a hangover treatment. Methods have been developed to extract ampelopsin from it at large scales, and laboratory research has been conducted with the compound to see if it might be useful as a drug in any of the conditions for which the parent plant has been traditionally used. In a trial of sixty patients with fatty liver disease, dihydromyricetin improved glucose and lipid metabolism and exerted anti-inflammatory effects which were beneficial. Dihydromyricetin shows promise as an alcohol anti-intoxicant.
DHM (Dihydromyricetin) is an organic compound naturally found in the Japanese Raisin Tree. It’s often called by it is Latin classification Hovenia Dulcis, and is found all over Asia. As a deciduous tree, it grows up to 12m tall and bears a berry-like fruit that tastes similar to raisins, from which it gets its name. Hovenia Dulcis, an Asian traditional herb, can offer numerous natural benefits and has been used in Asia for thousands of years.
The molecule we know as Dihydromyricetin is also called Ampelopsin, and is extracted using an ethanol-based solution from the bark of the Hovenia Dulcis tree. It's then minimally processed before it's dehydrated and turned into a powder ready to be purified.
(+)-Dihydromyricetin is an optically active form of dihydromyricetin having (2R,3R)-configuration. It has a role as a metabolite, an antioxidant, and an antineoplastic agent. It is a secondary alpha-hydroxy ketone and a dihydromyricetin. It is an enantiomer of a (-)-dihydromyricetin.
The main active ingredient in vine tea is flavonoids and Dihydromyricetin is a kind of special flavonoids, These substances have many special effects such as scavenging free radicals, anti-oxidation, anti-thrombosis, anti-tumor, and anti-inflammatory. Myricetin is a special flavonoid compound. In addition to the general characteristics of flavonoids, it also has the effects of relieving alcoholism, preventing alcoholic liver, fatty liver, inhibiting hepatocyte deterioration, and reducing the incidence of liver cancer.
Dihydromyricetin toxicity is small, with a variety of biological activity, its antioxidant effect can remove oxygen free radicals, inhibit oxygen free radicals on human tissues and organs damage, to prevent oil and other food oxidation deterioration, but also as milk and other food preservative Agent. Its anti-bacterial anti-inflammatory effect can be used for the treatment of infectious diseases such as stomatitis, pharyngitis, its inhibition of tumor cells, the blocking effect of HIV infection, liver function, blood sugar, blood lipid regulation, relaxation vascular smooth muscle And the role of antihypertensive, is expected to develop people urgently need drugs or health food.
In recent years, anti-tumor pharmacodynamics study found that one of its active ingredients, snake grapefruit small molecule compounds have a strong anti-cancer effect. Dihydromyricetin research has been in the preparation of anti-leukemia and nasopharyngeal carcinoma drug applications in the field of invention patents granted. It has been ready for a class of new drugs into the clinical trial phase. The development of new Chinese medicine snake grapefruit injection is expected for the majority of leukemia, nasopharyngeal cancer patients to provide a new treatment drug. Dihydromyricetin is now widely used in the treatment of respiratory infections, the lifting of alcoholism, liver and liver protection of traditional Chinese medicine preparations, such as tablets, capsules, granules.
The diamine is six light-yl myricetin Huang, anti-inflammatory, prostaglandin synthesis inhibition, inhibition of cell proliferation and relaxation of smooth muscle cells. Diamine myricetin as therapeutic agents benign prostatic hyperplasia.
The main active ingredient in vine tea is flavonoids. Ampelopsin(AMP) is one of the most important flavonoids found in Rattan tea. The flavonoids contain ampelopsin/ dihydromyricetin, myricetin, quercetin, quercetin-5-O-β–D-glucoside, taxifolin, apiin etc. The content of dihydromyricetin is highest in vine tea, especially inspire of vine tea.
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