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Last modified
09/20/2018 - 09:33

L-Carnitine

Product Details

Name L-Carnitine
Alias carnus
CAS  No. 541-15-1
Formula C7H15NO3
Weight 161.199 g/mol
Usage Pharmaceuticals / Diet Pills
Appearance White crystalline powder

Product Description

L-Carnitine is an amino acid known for promoting growth and development, fat-burning, increasing energy, and improving resistance to muscle fatigue. It is also great in dieting, as it can reduce feelings of hunger and weakness.

Carnitine ( β-hydroxy-γ- N -trimethylaminobutyric acid , 3-hydroxy-4- N , N , N -trimethylaminobutyrate ) is a quaternary ammonium compound involved in metabolism in most mammals, plants and some bacteria.

Carnitine may exist in two isomers, labeled D-carnitine and L-carnitine, as they are optically active. At room temperature, pure carnitine is a white powder, and a water-soluble zwitterion with low toxicity. Carnitine only exists in animals as the L - enantiomer, and D-carnitine is toxic because it inhibits the activity of L -carnitine. Carnitine, derived from an amino acid, is found in nearly all organisms and animal tissue.

Carnitine is the generic expression for a number of compounds that include L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine. It is most accumulated in cardiac and skeletal muscles as it accounts for 0.1% of its dry matter. It was first derived from meat extracts in 1905, therefore the name carnitine is derived from Latin " carnus " or flesh. The body synthesizes enough carnitine from lysine side chains to keep up with the needs of energy production in the body as carnitine acts as a transporter of long-chain fatty acids into the mitochondria(to be oxidized and produce energy.). Some individuals with genetic or medical disorders (like preterm infants) cannot make enough, so this makes carnitine a conditionally essential nutrient for them.

Earlier studies found that L-carnitine is a vitamin-like nutrient and named it vitamin Bt. In fact, the chemical structure of the base is similar to that of choline, which is similar to amino acids. In addition, since some animals can be synthesized by themselves to satisfy the needs of carnitine, it is considered that carnitine is not a vitamin, but it is still called vitamin BT.

 

Function

The main role of L-carnitine is to help transport long-chain fatty acids to provide energy. This prevents fat from accumulating in the heart, liver and skeletal muscles. It can prevent fatty metabolism disorders in diabetes, fatty liver and heart disease. Taking carnitine can reduce heart damage. It can reduce triglycerides in the blood and has a certain effect on weight loss. Carnitine can strengthen the antioxidant effects of vitamin E and vitamin C. The synthetic carnitine has three forms: left-handed body, right-handed body and racemic body, and the effect of L-carnitine is better.

L-carnitine, also known as L-carnitine, has a chemical structure similar to choline and is similar to amino acids, but it is not an amino acid and cannot participate in the biosynthesis of proteins. Since L-carnitine can be physiologically synthesized by humans and most animals through its own body synthesis, it is not a true vitamin, but a vitamin-like substance.

If there is abundant iron, thiamine, vitamin B6, lysine, methionine and vitamin C in the body, carnitine will not be lacking. Carnitine-rich foods are meat and internal organs.

L-carnitine is a compound with many physiologically active functions. Its main function is to promote β-oxidation of fatty acids. It can also regulate the ratio of acyl groups in mitochondria and affect energy metabolism. L-carnitine can participate in the transport of branched-chain amino acid metabolites. Thereby promoting the normal metabolism of branched chain amino acids.

In addition, L-carnitine plays a role in the elimination and utilization of ketone bodies and can be used as a biological antioxidant to scavenge free radicals, maintain membrane stability, improve animal immunity, and resist disease and stress.

L-carnitine can be combined with a large number of acyl-Coenzyme derivatives produced in organic acid and fatty acid metabolism diseases and converted into water-soluble acylcarnitine from the urine, which is helpful for the control of acute acidosis.

Recent studies have shown that L-carnitine and acetyl L-carnitine play an important role in the energy metabolism of sperm mitochondria, which can scavenge ROS and protect sperm membrane function. Oral L-carnitine and acetyl L-carnitine can improve the total number of sperm in the forward movement and the total number of sperm in the exercise, and improve the clinical pregnancy rate of the woman, and it is safe and effective. Clinical laboratory studies at home and abroad have shown that carnitine treatment of male infertility is a new breakthrough in the field of male infertility drug treatment in recent years, and its in-depth study is necessary to further clarify its mechanism of action and clarify its indications.

L-carnitine is not a weight-loss drug. Its main function is to transport fat to the mitochondria for burning. It is a carrier enzyme. To lose weight with L-carnitine, you must control your diet with proper exercise.

 

Application

L-carnitine has been used in the fields of medicine, health care, and food, and has been regulated as a legal multi-purpose nutrient by Switzerland, France, the United States, and the World Health Organization.

L-carnitine and weight loss
L-carnitine is a key substance in the process of fat metabolism, which can promote the oxidative decomposition of fatty acids into mitochondria. It can be said that carnitine is a carrier for transporting fatty acids. In long-term high-intensity exercise, carnitine increases the rate of fat oxidation, reduces the consumption of glycogen, and also delays fatigue.

L-carnitine is an essential coenzyme in fat metabolism, which promotes the oxidative decomposition of fatty acids into mitochondria. If fat does not enter the mitochondria, no matter how you exercise, how to diet, you can not consume it (fat).
As a key substance in the β-oxidation of fatty acids, L-carnitine can remove excess fat and other fatty acid residues in the body to balance the energy in the cells. L-carnitine really meets the three criteria for healthy weight loss stipulated by the World Health Organization (WHO) in the process of weight loss: no anorexia, no diarrhea, no fatigue.

L-carnitine and food (as a supplement or health supplement)

  • Increase endurance and improve athletic performance
  • Promote fatigue recovery
  • Delaying the aging process
  • Good for baby health

Medical use of L-carnitine

  • Good for heart and blood vessels
  • Helps eliminate fatty liver
  • Treatment of hemorrhagic shock
  • Male infertility
  • Atherosclerosis
  • Cancer
  • Diabetes mellitus type 2
  • AIDS and HIV
  • End-stage renal disease and Hemodialysis

Many people have concerns about the safety of L-carnitine. In fact, there is no need to worry. The safety of using L-carnitine is much higher than that of most vitamins.

L-carnitine is a kind of vitamin derived from red meat such as beef and pork. It can also be synthesized by the human body. It is the best and safe nutrient for weight loss. Since it is derived from food and the body itself can be synthesized, it is not a slimming drug and a health supplement, so there is no side effect.

L-carnitine History related

  • Especially in 1982, after the Italian football player took L-carnitine to win the World Cup, L-carnitine became popular in the world and became the new favorite of nutritional supplements. Many high-tech weight loss products use L-carnitine as one of the main components of weight loss. L-carnitine, let your fat burn in time, will make you healthy, slim, and have a charming body.
  • In 1989, the Food and Nutrition Board (FNB) concluded that carnitine wasn't an essential nutrient as healthy human liver and kidneys synthesize sufficient quantities of carnitine from lysine and methionine to meet up with daily body requirements without the need of consuming it from supplements or food.

 

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