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Sibutramine Hydrochloride is a serotonin and norepinephrine reuptake inhibitor with dual effects of appetite suppression, and has been used for short- and long-term therapy of obesity, but which was withdrawn from use in 2010 because of increase risk of cardiovascular events.
Mainly through its amine (secondary amine and primary amine) metabolites and effect, the main mechanism for the inhibition of norepinephrine and serotonin and dopamine reuptake and enhance the sense of satiety, and norepinephrine, serotonin, and does not affect the release of dopamine. Studies have also shown that this product has no obvious and amine active metabolites against choline, antihistamines and monoamine oxidase inhibiting effect.
Sibutramine is an orally administered serotonin and noradrenaline reuptake inhibitor that is indicated as adjunctive therapy for adult patients within a weight management programme, including weight loss and maintenance of weight loss.
It inhibits hunger by suppressing serotonin replenishment and suppresses appetite to effectively control caloric intake; Adrenergic receptor by activating the other hand, the consumption of fat tissue increased, enhanced metabolism and energy expenditure; having a significant weight loss, However, it may cause serious side effects such as elevated blood pressure, increased heart rate, anorexia, insomnia, and abnormal liver function.
Sibutramine hydrochloride was first used to treat depression. In its clinical application, it was found that its weight loss was significantly stronger than its antidepressant effect.
- Used as an antidepressant
- Used as the main component of the diet pills
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