Voriconazole is an antifungal medication used to treat a number of fungal infections. It is a broad-spectrum triazole antifungal drug used primarily to treat progressive, It works by affecting the cell membrane or affecting fungal metabolism.
This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. It can be taken by mouth or used by injection into a vein.
The mechanism is inhibiting fungi mediated by cytochrome P450 14 alpha sterol to methylation, thus inhibiting ergosterol biosynthesis. In vitro experiments showed that voriconazole broad-spectrum antifungal effect. The product of candida (including resistant to fluconazole, soft candida, smooth candida and drug resistance in c. albicans strains) have an antibacterial effect, for some bacterium fungi have an antiseptic effect.
Voriconazole used primarily to treat progressive, potentially life-threatening infections in immunodeficient patients. Indications include: severe fungal infections in immunosuppressed patients, acute invasive aspergillosis (the most common pathogen is Aspergillus fumigatus, followed by Aspergillus flavus, Aspergillus niger and Aspergillus terreus), caused by fluconazole-resistant Candida Severe invasive infections (including Candida krusei), severe infections caused by the pathogens and Fusarium. Patients with moderate to severe renal insufficiency should be administered intravenously with caution.
Voriconazole is well absorbed orally with a bioavailability of 96%, allowing patients to be switched between intravenous and oral administration.
Voriconazole was approved for medical use in the United States in 2002. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Generic versions have been approved.
Voriconazole is used to treat invasive aspergillosis and candidiasis and fungal infections caused by Scedosporium and Fusarium species, which may occur in immunocompromised patients, including people undergoing an allogeneic bone marrow transplant (BMT), who have hematologic cancers or who undergo organ transplants.
It is used to prevent fungal infection in people as they undergo BMT, and also the recommended treatment for the CNS fungal infections transmitted by epidural injection of contaminated steroids.
It can be taken by mouth or given in a doctor's office or clinic by intravenous infusion.
Voriconazole is an ergosterol biosynthesis inhibitor, as well as systemic antifungal. This compound, like many antifungal agents, is an inhibitor of CYP2C9, an enzyme involved in the oxidative metabolism of many xenobiotics. Voriconazole is an inhibitor of CYP51A1.
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