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11-dehydro Thromboxane B2 EIA Kit

Synonyms : 11-dehydro TXB2 ELISA Kit - Monoclonal
Stability : 1 year
Description :
TXB2 can be metabolized by 11-hydroxy thromboxane dehydrogenase to form 11-dehydro TXB2, or by β-oxidation to form 2,3-dinor TXB2. Infusion studies using TXB2 have shown that both metabolites are formed equally, although 11-dehydro TXB2 has a longer circulating half-life (t½ = 45 minutes). Therefore, measurement of 11-dehydro TXB2 in plasma or urine will give a time-integrated indication of TXA2 production. Normal plasma levels of 11-dehydro TXB2 (1-2 pg/ml) are below the detection limit of this assay (10 pg/ml), so plasma samples must be purified and concentrated prior to analysis. Because urine contains many possible crossreacting eicosanoid metabolites, it is prudent to purify urine also. This assay has been validated by comparison to GC/MS.
Specificity :
11-dehydro Thromboxane B2 100% 
11-dehydro-2,3-dinor Thromboxane B2 330% 
Prostaglandin D2 0.12%
Storage : -20°C

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