Multiple furnishings of magnesium isoglycyrrhizinate on the disposition of docetaxel in docetaxel-induced alarmist injury
Magnesium isoglycyrrhizinate (MgIg) has been abundantly acclimated in alleviative alarmist abrasion which is the accepted adverse acknowledgment of docetaxel (DOC). Due to the attenuated ameliorative window, baby changes in pharmacokinetic profiles can adapt the toxicity and ameliorative ability of DOC significantly. The abstraction aimed to analyze the furnishings of Magnesium isoglycyrrhizinate on the disposition of DOC and the abeyant apparatus in DOC-induced alarmist injury.
Pharmacokinetics and tissues administration behaviors showed that there was no cogent aberration amid DOC accumulation (DOCG) and MgIg + DOC accumulation (MDOCG).
The mRNA and protein levels of cytochrome P450 3A1 (CYP3A1) in liver, intestine, and branch were decidedly upregulated, and the P-glycoprotein (P-gp) was acutely downregulated in MDOCG if compared with DOCG.
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