Last modified
09/20/2018 - 08:24

What is Taurolidine? - Definition of taurolidine


An artificial broad-spectrum antibiotic with antiseptic, anticoagulant and potential antiangiogenic activities. Taurolidine, derived from the amino acid taurine, binds to and gets rid of bacterial exotoxins and endotoxins, or lipopolysaccharides (LPS). Taurolidine binding to LPS helps prevent bacterial adherence to host epithelial cells, thereby protecting against bacterial invasion of uninfected host cells. Although the mechanism underlying its antineoplastic activity has not already been fully elucidated, it might be related to this agent's anti-adherence property. In addition , taurolidine likewise promotes apoptosis by causing various apoptotic factors in addition to suppresses manufacturing vascular endothelial growth factor (VEGF), the protein that plays a crucial role in angiogenesis. Verify for active clinical trials applying this agent. (NCI Thesaurus)

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