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Last modified
11/27/2018 - 04:20


Product Details

Name Hypromellose
Alias HPMC; Hydroxypropyl Methylcellulose
CAS  No. 9004-65-3
Formula C8H15O6–(C10H18O6)n–C6H15O5 (variable)
Weight variable g/mol
Usage Cosmetics / Pharmaceuticals
Appearance White powder

Product Description

Hypromellose, also known as hydroxypropyl methylcellulose, abbreviated HPMC, is a species of nonionic cellulose mixed ether. It is a semi-synthetic, inactive, viscoelastic polymer that is commonly used in ophthalmology as a lubricant or as an excipient or excipient in oral medications and is found in a wide variety of commodities. As a food additive, hypromellose can play the role of emulsifiers, thickeners, suspending agents and animal gelatin substitutes.

Hydroxypropyl methylcellulose is a propylene glycol ether of methylcellulose in which the hydroxypropyl group and the methyl group are combined with an ether bond and an anhydrous glucose ring of cellulose, and are white to off-white cellulose powder or granules having Similar to methylcellulose, cold water dissolution and hot water insoluble characteristics. It has better solubility in organic solvents than water can be dissolved in anhydrous methanol and ethanol solution, and can also be dissolved in organic solvents such as chlorinated hydrocarbons and ketones. Dissolved in water, its aqueous solution is surface active, forms a film after drying, and undergoes reversible conversion from sol to gel after heating and cooling.

Hypromellose is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules. The compound forms colloids when dissolved in water. This non-toxic ingredient is combustible and can react vigorously with oxidizing agents.

Hypromellose in an aqueous solution, unlike methylcellulose, exhibits a thermal gelation property. That is, when the solution heats up to a critical temperature, the solution congeals into a non-flowable but semi-flexible mass. Typically, this critical (congealing) temperature is inversely related to both the solution concentration of HPMC and the concentration of the methoxy group within the HPMC molecule ,which in turn depends on both the degree of substitution of the methoxy group and the molar substitution. That is, the higher the concentration of the methoxy group, the lower the critical temperature. The inflexibility/viscosity of the resulting mass, however, is directly related to the concentration of the methoxy group.


The finished product of hydroxypropyl methylcellulose was a white powder or a white loose fibrous solid with a particle size passing through an 80 mesh sieve. The ratio of the methoxy group content to the hydroxypropyl group content of the finished product is different, and the viscosity is different, and it becomes various varieties having different performances. It has the characteristics of cold water dissolution and hot water insolubility similar to methylcellulose, and its solubility in organic solvents is more than water solubility, soluble in anhydrous methanol and ethanol, and soluble in chlorinated hydrocarbons such as dichloro. Methane, trichloroethane, and organic solvents such as acetone, isopropanol, and diacetone alcohol. When dissolved in water, it combines with water molecules to form a colloid. It is stable to acids and bases and is not affected in the range of pH=2~12. Hypromellose, although non-toxic, is flammable and produces a violent chemical reaction with oxidants.

The viscosity of HPMC products increases with increasing concentration and molecular weight. When the temperature rises, the viscosity begins to decrease. When the temperature reaches a certain temperature, the viscosity suddenly rises and gels. The gel temperature of low viscosity products is higher than that of high viscosity products. height of. Its aqueous solution is stable at room temperature, except for the degradation of the enzyme, the general viscosity is not degraded. It has special thermal gelation properties, good film-forming properties and surface activity.


The use of hydroxypropyl methylcellulose is similar to other cellulose ethers and is mainly used as a dispersant, suspending agent, thickener, emulsifier, stabilizer and adhesive in various fields. It is superior to other cellulose ethers in terms of solubility, dispersibility, transparency and enzyme resistance.

Used in the food and pharmaceutical industries as an additive, as a binder, thickener, dispersant, due to its adhesion, film-forming properties, thickening and dispersion in liquids, and penetration of oil and moisture. Relief, stabilizer and emulsifier. It is non-toxic, has no nutritional value, and does not metabolize.

In addition, HPMC has applications in synthetic resin polymerization, petrochemicals, ceramics, paper, leather, cosmetics, coatings, building materials and photosensitive printing plates.

There are many fields of application for hypromellose, including:

  • Tile adhesives
  • Cement renders
  • Gypsum products
  • Pharmaceutical
  • Paints & coatings
  • Food
  • Cosmetics
  • Detergents & cleaners
  • Eye drops
  • Contact lenses

This product is used as a thickener, dispersant, binder, emulsifier and stabilizer in the textile industry. Also widely used in synthetic resins, petrochemicals, ceramics, paper, leather, medicine, food, cosmetics and other industries.

Used in synthetic resins, petrochemicals, ceramics, paper, leather, textile printing, pharmaceuticals, food, cosmetics and other household chemicals, as dispersants, thickeners, binders, excipients, capsules, oil resistant coatings and Filler, etc.

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