|Alias||Analgin / Dipyrone|
|Usage||Cosmetics / Pharmaceuticals|
Metamizole sodium ( or dipyrone, Analgin), is a painkiller, spasm reliever and fever reliever. It indicated for treating diseases caused by high fever and various pain. It is also indicated in fever, headache, rheumatic pain, neuralgia and dysmenorrheal etc. It is freely soluble in water and rapidly effects. It is a sulfonic acid and comes in calcium, sodium and magnesium salt forms. Its sodium salt monohydrate form is a white/almost crystalline powder that is unstable in the presence of light, highly soluble in water and ethanol but practically insoluble in dichloromethane.
Its precise mechanism of action is unknown, although it is believed that inhibiting brain and spinal cord prostaglandin (fat-like molecules that are involved in inflammation, pain and fever) synthesis might be involved.
Recently, researchers uncovered another potential mechanism involving metamizole being a prodrug. In this proposal, not yet verified by other researchers, the metamizole itself breaks down into other chemicals that are the actual active agents. The result is a couple of cannabinoids and NSAID arachidonic acid conjugates(although not in the strict chemical meaning of the word) of metamizole's breakdown products.
Despite this studies in animals have found that the CB1 cannabinoid receptor is not involved in the analgesia induced by metamizole. Although it seems to inhibit fevers caused by prostaglandins, especially prostaglandin E2. It appears to produce its therapeutic effects by means of its metabolites, especially N-methyl-4-aminoantipyrine (MAA) and 4-aminoantipyrine (AA).
Metamizole sodium has detoxification, analgesic and anti-rheumatic effects. Mainly used for antipyretic, also used for acute arthritis, rheumatic pain, muscle pain, headache, etc.
It is primarily used for perioperative pain, acute injury, colic, cancer pain, other acute/chronic forms of pain and high fever unresponsive to other agents.
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