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Last modified
09/03/2018 - 03:34

Sulfacetamide

Product Details

Name Sulfacetamide
Alias Acetosulfamine / Acetosulfamin / Acetocid
CAS  No. 144-80-9
Formula C8H10N2O3S
Weight 214.243 g/mol
Usage Lotion / Pharmaceuticals
Appearance White or light yellow crystalline powder

Product Description

Sulfacetamide is a white to pale yellow crystalline powder chemicals(At room temperature, it appears as a white powder.). The chemical name is N-(4-aminobenzenesulfonyl)acetamide, the molecular formula is C8H10N2SO3, and the molecular weight is 214.242. Sulfaacetin is an anti-infective drug. It is mainly used for ocular infections such as bacterial superficial conjunctivitis, keratitis, mumps and orbital inflammation. It is used for trachoma and fungal keratitis caused by Chlamydia trachomatis. adjuvant therapy, trauma, chronic dacryocystitis, conjunctiva and cornea before and after surgery to prevent infection.

 

Function

Sulfacetamide is a sulfonamide antibiotic. Sulfonamides are synthetic bacteriostatic antibiotics, that are active against gram-positive and gram-negative bacteria. It blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. It is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA).PABA is required for bacterial synthesis of folic acid and it is an essential component for bacterial growth. The multiplication of bacteria is therefore inhibited by the action of sulfacetamide.

Sulfacetamide is a sulfonamide antibiotic, that is used as a cream to treat skin infections and as eye drops to treat eye infections. On the skin, it is used to treat acne and seborrheic dermatitis. In cream form, it is used to treat bacterial infections on the skin. It can also be used orally to treat urinary tract infections. It kills the bacteria by restricting the production of folic acid, which is essential for bacterial growth. It mainly inhibits the multiplication of bacteria as it acts in a competitive inhibitor.

 

Application

Sulfacetamide as a medicine is available as solution, eye drops, lotion, and powder.Medicine for the treatment of conjunctivitis, blisters and other eye infections. It is mainly used to treat sulphate such as conjunctivitis, blisters and other eye infections, or to treat infections caused by bacteria.

Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis. When combined with sulfur, it is sold under the brand names Plexion, Clenia, Prascion, and Avar, which contain 10% sulfacetamide and 5% sulfur.

Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor and rosacea.  It also has anti-inflammatory properties when used to treat blepharitis or conjunctivitis (in eye-drop solution). It is believed to work by limiting the presence of a folic acid which bacteria need to survive. It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa. Sulfacetamide has antibacterial activity and is used to control acne. Products containing sulfacetamide and sulfur (a keratolytic) are commonly promoted for the treatment of acne rosacea (rosacea with papules, pustules, or both). There are several prescription topical products containing sulfacetamide, such as foams, shampoos, cream, and washes.

Some research indicates that sulfacetamide derivatives may act as antifungals by a CYP51A1-independent mechanism.

 

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