PGE1 (Prostaglandin E1) Information
Prostaglandin E1 is the abstract cyclooxygenase metabolite of dihomo-γ-linolenic acerbic (DGLA), but it is around ephemeral in the claret of accustomed bodies or added animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced animal platelet accession is 40 nM. The vasorelaxant and anti-hypertensive furnishings of PGE1 are acclimated to amusement macho arrect dysfunction and to accommodate emergency vasodilation of the apparent autography arteriosus in breed whose cardiac anomalies crave pulmonary shunting for survival. In animal males, the intracavernosal able dosage ambit for PGE1 is 2 to 80 µg, and the transurethral ambit is 125 to 1,000 µg.
Prostaglandin E1 (PGE1) is a above prostaglandin begin in animal berry that inhibits platelet aggregation. The admixture has accurate abrasion Ki ethics of 1.1, 2.1, 3.6, 10 and 13 nM for the corresponding receptors EP3, EP4, EP1, EP2 and IP. Aside from the action at EP receptors, PGE1 has aswell been apparent to affect PKC, calcium movement, and adenylate cyclase acquiescent a aggregation of physiological effects.
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