Protective Effect of Magnesium Isoglycyrrhizinate on Ethanol-Induced Testicular Injuries in Mice
Ethanol analysis induces an access in oxidative stress. As licorice compounds are almighty antioxidants, our aim was to appraise whether magnesium isoglycyrrhizinate attenuated lipid peroxidation, the above end-point of oxidative accident consistent from booze administration.
Four groups(18 animals in anniversary group) of macho Kunming mice were used. The aboriginal accumulation served as ascendancy and accustomed 0.4 ml accustomed acrid circadian for 18 canicule orally. The additional accumulation of mice was accustomed 56% booze at 16 ml/kg physique weight per day for 18 canicule orally. The third accumulation was accustomed the aforementioned dosage of booze and administrated magnesium isoglycyrrhizinate (15 mg/kg.d, i.p.) for 18 days. The fourth accumulation was accustomed the aforementioned dosage of booze and administrated with magnesium isoglycyrrhizinate (45 mg/kg.d, i.p.) for 18 days. Twenty four hours afterwards 9 canicule or 18 canicule of analysis the mice were sacrificed application 10% chloral hydrate. Sperm counts and activity in the epididymis were assessed. The lipid peroxidation and antioxidants of testicular mitochondria were aswell determined. The dissection changes of testicle tissue of the mice were empiric by ablaze microscopy.
Magnesium isoglycyrrhizinate finer prevented the ethanol-induced seminiferous epithelium chaos and decline of Sertoli beef and antibody cells. Sperm counts and activity of the magnesium isoglycyrrhizinate advised groups were college than those of the booze advised group, but were lower than those of the ascendancy group. The biologic apparent an adeptness to annul booze induced oxidative claiming as it finer bargain testicular malondialdehyde (MDA) and added the activities of superoxide dismutase and glutathione peroxidase.
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