The use of HDAC6 (human recombinant)
HDAC6 is a class II HDAC, a group defined by its member’s homology to the yeast HDAC HDA1, which is unique among human HDACs in that it contains two full deacetylase domains. A tubulin deacetylase, HDAC6 may act to promote autophagic clearing of huntingtin aggregates and retard HIV1 infection, but also to promote invasive motility in tumor cells.
HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrate. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.
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