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Last modified
05/26/2018 - 07:36

13,14-dihydro-16,16-difluoro Prostaglandin E1

Product Description

CAS Number : 475992-30-4
Molecular Formula : C20H34F2O5
Formula Weight : 392.5g/mol
Specification : 
Formulation:A solution in methyl acetate
Stability:1 year
Description :
Prostaglandin E1 (PGE1) is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM) and increases vasodilation. 13,14-dihydro-16,16-difluoro PGE1 is an analog of PGE1. 13,14-dihydro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound. The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo.
Storage : -20°C

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