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Last modified
05/26/2018 - 08:08

Acetyl Lysine Polyclonal Antibody-biotin

Product Description

Stability : 1 year
Storage : -20°C
Formulation :
400 µl (0.25 mg/ml) of rabbit immunoglobulin in PBS containing 0.01% sodium azide
Description :
Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of lysine involves acetylation. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Protein post-translational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progession, apoptosis, DNA repair, and cytoskeletal orgnization. The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development.

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