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Last modified
05/26/2018 - 08:10

Akt1 Polyclonal Antibody

Product Description

Stability : 1 year
Storage : -20°C
Formulation : protein G-purified IgG in 200 µl PBS containing 0.2% sodium azide
Description :
WB · Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. Akt/PKB phosphorylation is critical for its activity. The major phosphorylation sites required for Akt activation have been identified as threoinine 308 and serine 473. Serine 473 is phosphorylated by MAPKAP kinase 2. 

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