Last modified
05/26/2018 - 07:53


Product Description

CAS Number : 1159576-98-3
Molecular Formula : C22H18ClNO3
Formula Weight : 379.8g/mol
Specification : 
Formulation:A crystalline solid
Stability:2 years
Description :
CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.
Storage : -20°C

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