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Last modified
05/26/2018 - 09:19

Cystathionine γ-Lyase

Product Description

Formulation : 70 mM Tris, pH 8.1, containing 150 mM sodium chloride, 20% glycerol, and 10 µM Pyridoxal-5’-Phosphate
Purity : ≥85%
Stability : 6 months
Storage : - 80°C
Description :
Recombinant protein expressed in E. coli · Mr: 44.5 kDa · Transsulfuration and reverse transsulfuration comprise part of the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine. Reverse transsulfuration is catalyzed by the enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CGL) in fungi and mammals.1 Specifically, CGL catalyzes the conversion of cystathionine to cysteine in a Pyridoxal-5'-Phosphate-dependant reaction. At elevated levels, homocysteine is an independent risk factor for cardiovascular diseases and other complex disorders.The mammalian transsulfuration pathway is one of two major metabolic routes for homocysteine removal. Besides homocysteine removal, transsulfuration contributes significantly to the intracellular cysteine pool. Cysteine is used for biosynthesis of glutathione, and is also the primary substrate for H2S biosynthesis. CGL is one of two major enzymes that catalyzes the formation of H2S from cysteine.  H2S generation is a biological gasotransmitter, a neuromodulator, a vasodilator, and plays an important role in inflammation.

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