25 Years Of Pharmaceuticals and Healthy&Cosmetic Ingredients Manufacturer & Supplier & Exporter.

Last modified
05/26/2018 - 07:33

(E)-Guggulsterone

Product Description

CAS Number : 39025-24-6
Molecular Formula : C21H28O2
Formula Weight : 312.5g/mol
Specification : 
Formulation:A crystalline solid
Purity:≥98%
Stability:2 years
Description :
Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis. Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo. The cis stereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 15 µM.  By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.
Storage : -20°C

Send inquiry online For more product information and prices

(Pharmaceutical Ingredients Manufacturer & Supplier & Exporter.)

After sending the online inquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email. —— Green Stone Swiss

Email: [email protected]
Tel: +86 592 5365887
WhatsApp: +86 189 6515 7632
Send inquiry online: