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Last modified
05/26/2018 - 08:22

FoxP3/Scurfin Polyclonal Antibody

Product Description

Formulation : 100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide
Stability : 1 year
Storage : -20°C
Description :
IHC and WB · One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens are regulatory T-cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over-expression studies have led to the identification of FoxP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FoxP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FoxP3 as a critical player in the negative control of various normal and pathological immune responses holds great promise for the development of novel therapies for autoimmune diseases. 

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