Last modified
05/26/2018 - 08:53

JZL 195

Product Description

CAS Number : 1210004-12-8
Molecular Formula : C24H23N3O5
Formula Weight : 433.5g/mol
Specification :
Formulation:A crystalline solid
Stability:2 years
Description :
Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide and 2-arachidonoylglycerol, respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively).1 It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.1 The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Catalog No. 13279) and JZL 184 (Catalog No. 13158), respectively.1 Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.1 
Storage : -20°C

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