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Last modified
05/26/2018 - 02:21


Product Description

CAS : 103253-15-2
Molecular Formula : C21H21ClFNO2
Formula Weight : 373.9g/mol
Specification :
Stability:2 years
Formulation:A crystalline solid
Description : 
The lipid mediator thromboxane (TX)A2 plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA2 are mediated by its specific G protein-coupled receptor, referred to as the TXA2 receptor or TP. Two isoforms, TPα and TPβ, are produced from a single gene, differ in their carboxyl termini, and form homo- and hetero-oligomers. While both isoforms signal through similar pathways, they differ in the modulation by certain agonists. L-655,240 is a potent antagonist of the TP receptor in vitro (IC50 = 7 nM) It also is effective at blocking TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Whether the two TP isoforms differ in their sensitivity to L-655,240 is not known. 
Storage : -20°C

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