Last modified
05/26/2018 - 02:58

MS-275

Product Description

CAS Number : 209783-80-2
Molecular Formula : C21H20N4O3
Formula Weight : 376.4g/mol
spcification
Purity:≥98%
Stability:2 years
Formulation:A crystalline solid
Description :
MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).1 However, it does not inhibit HDAC8 (IC50 > 100 μM).1 MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo.23 Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin,4 inhibitors of poly (ADP-ribose) polymerase (PARP),5 or inhibitors of heat shock protein 90 (Hsp90).
Storage : -20°C

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