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Last modified
05/26/2018 - 08:49

MyD88 Homodimerization Inhibitory Peptide Set

Product Description

Formulation : A lyophilized solid
Stability : 1 year
Storage : -20°C
Description :
MyD88 is an adapter protein that links toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) with downstream signaling molecules. Homodimerization of MyD88 is a critical step in the signaling process and allows the recruitment and activation of the kinase IRAK. MyD88 exists as a homodimer when recruited to activate TLR/IL-receptors (TIR). The inhibitor peptide contains a sequence from the MyD88 TIR homodimerization domain.1 MyD88 monomer binds to this inhibitor peptide, thereby blocking Myd88 homodimerization. The MyD88 homodimerization inhibitory peptide contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2 The control peptide consists of only the PTD sequence. 

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