25 Years Of Pharmaceuticals and Healthy&Cosmetic Ingredients Manufacturer & Supplier & Exporter.

Last modified
05/26/2018 - 09:15

NF-κB (p65) (Ser529,536) Inhibitory Peptide Set

Product Description

Formulation : A lyophilized solid
Stability :1 year
Storage : -20°C
Description :
NF-κB has been shown to regulate the expression of a number of genes whose products are involved in inflammation, viral replication, carcinogenesis, apoptosis, invasion, and metastasis. Specific adhesion molecules, chemokines, inflammatory cytokines, and cell cycle regulatory genes are affected. Thus, agents that can suppress NF-κB activation have the potential to be treatments for inflammatory diseases and cancer. The Ser529,536 sites of p65 are phosphorylated during NF-κB activation, allowing p65 nuclear translocation. This p65 inhibitory peptide contains the Ser529,536 sites that are phosphorylated during NF-κB activation, thereby blocking p65 phospho-Ser529,536 phosphorylation. The NF-κB (p65) (phospho-Ser529,536) inhibitor peptide can inhibit binding of recombinant p65 protein to DNA in a dose-dependent manner with maximum inhibition occuring at 50 µM. It can also inhibit TNF-induced NF-κB activation in cells. The NF-κB (p65) (Ser529,536) inhibitory peptide also contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permable.1 The control peptide consists of only the PTD sequence.

Send inquiry online For more product information and prices

(Pharmaceutical Ingredients Manufacturer & Supplier & Exporter.)

After sending the online inquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email. —— Green Stone Swiss

Email: [email protected]
Tel: +86 592 5365887
WhatsApp: +86 189 6515 7632
Send inquiry online: