Last modified
05/26/2018 - 08:34

PF-3845

Product Description

CAS Number : 1196109-52-0
Molecular Formula : C24H23F3N4O2
Formula Weight : 456.5g/mol
Specification : 
Formulation:A crystalline solid
Purity:≥98%
Stability:2 years
Description :
Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM).1 It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment.1 PF-3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.1
Storage : -20°C

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