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Last modified
05/26/2018 - 08:43

SC-51089

Product Description

CAS Number : 146033-02-5
Molecular Formula : C22H19ClN4O3 • HCl
Formula Weight : 459.3g/mol
SPecification :
Formulation:A crystalline solid
Purity:≥95%
Stability:2 years
Description :
The prostaglandin E2 (PGE2) receptor EP1 is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51089 is a selective EP1 antagonist, first shown to have in vivo analgesic activity in mice (ED50 = 6.3 mg/kg when given subcutaneously) and in the rat.1,2 SC-51089 also inhibits the growth of glioma cell lines in vitro (IC50 = ~1 μM) and slows tumor growth in vivo.3 In addition, SC-51089 is neuroprotective, attenuating neuronal cell death in response to oxidative stress, an effect that is also found in EP1-/- mice and mediated by PGE2.4,5 
Storage : -20°C

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