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Last modified
05/26/2018 - 07:30


Product Description

CAS Number : 284028-89-3
Molecular Formula : C14H11F3N2OS
Formula Weight : 312.3g/mol
Specification : 
Formulation:A crystalline solid
Stability:2 years
Description :
XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 with IC50 values of 11 and 4 nM, respectively. By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells. At concentrations as low as 0.33 µM, XAV939 inhibits colony formation of APC-deficient colorectal cancer cells.
Storage : -20°C

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