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Last modified
05/26/2018 - 04:59

(Z)-Guggulsterone

Product Description

CAS Number : 39025-23-5
Molecular Formula : C21H28O2
Formula Weight : 312.5g/mol
Specification : 
Purity:≥98%
Stability:2 years
Formulation:A crystalline solid
Description :
The trans stereoisomer of guggulsterone, (Z)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 17 µM. By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet. While both cis and trans stereoisomers have been shown to directly decrease hepatic cholesterol, the Z isomer is the most studied. (Z)-Guggulsterone demonstrates antitumor-promoting effects inhibiting both constitutive and interleukin-6-induced STAT3 activation in human multiple myeloma cells and suppressing the VEGF-VEGF/R2-Akt signaling axis in DU145 human prostate cancer cells.
Storage : -20°C

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