Cytochrome P450 2B6 (human) Yeast Reductase

Product Description

Stability : 2 years
Description :
Mechanism-based inhibition of CYP2B6 in human liver microsomes by thienopyridine antiplatelet agents ticlopidine and clopidogrel and the thiolactone metabolites of those two agents plus that of prasugrel were investigated by determining the time- and concentration-dependent inhibition of the activity of bupropion hydroxylase as the typical CYP2B6 activity. CYP2B6 represents approximately 6% of the hepatic cytochrome P450 pool and demonstrates more than 100-fold interindividual variability in the activity. In addition, genetic polymorphism in CYP2B6 was shown to result in decreased enzyme activity. 
Storage : -80°C

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