Interleukin-1α (human) EIA Kit
Synonyms : IL-1α (human) ELISA Kit
Stability : 1 year
Interleukin-1 (IL-1) is a name for a family of proteins which includes IL-α, IL-1β, ILra (interleukin receptor antagonist) and IL-18. IL-1α is synthesized as a 33 kDa (271 amino acid) pro-cytokine that is enzymatically cleaved by calpain into the active 159 amino acid, 17 kDa peptide. IL-1α is produced by many cells types including macrophages, monocytes, astrocytes, keratinocytes, adipocytes, T-cells, and eosinophils. Although IL-1α and IL-1β exhibit only 26% amino acid identity, they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses. Normal production of IL-1 is critical for mediating host responses to infection and injury. Disease states in which IL-1 actively participates include inflammatory diseases such as arthritis, inflammatory bowel disease, and shock, as well as atherosclerosis, allergic disease, and some types of cancer.
Storage : -20°C
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