15-Lipoxygenase-1 Western Ready Control
Stability : 2 years
Laemmli buffer (2% SDS, 10% glycerol, 62.5 mM Tris-HCl, pH 6.8, containing 5% 2-mercaptoethanol, bromophenol blue)
15-Lipoxygenase-1 (15-LO-1) catalyzes the formation of 15(S)-HETE and 13(S)-HODE from arachidonic acid and linoleic acid, respectively. 15-LO-1 is a monomer with a molecular mass of approximately 75 kDa and is found primarily in reticulocytes and eosinophils. Interleukin-4 and -13 induce the expression of 15-LO-1 mRNA in human monocytes. The induction of 15-LO-1 by both agents is inhibited by IFNγ. A second 15-LO, 15-LO-2, cloned from human hair roots, has been identified. 15-LO-1 is expressed in prostate, lung, and cornea and exhibits approximately 40% identity to the 15-LO-2.
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