ChREBP DBD (human recombinant)

Product Description

Stability : 6 months
50 mM sodium phosphate pH 7.2, 100 mM sodium chloride, 1 mM DTT, and 40% glycerol
Description:ChREBP is phosphorylated which sequesters the transcription factor in the cytoplasm. Under conditions of elevated glucose, one of its metabolites, xylulose 5-phosphate, activates Protein Phosphatase 2A (PP2A) which dephosphorylates ChREBP at Ser. Dephosphorylated (Ser) ChREBP translocates into the nucleus where it is further dephosphorylated at Thr by PP2A. The second dephosphorylation allows ChREBP to bind to the carbohydrate response element (ChRE) within the promoter of the L-type pyruvate kinase (L-PK) gene, as well as a subset of lipogenic enzymes. Activation of ChREBP by high glucose in the liver occurs independent of insulin. The inactivation of ChREBP has been proposed as a potential method for reducing obesity and also improving glucose tolerance.
Purity : >85% by SDS-PAGE
Storage : -80°C

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