pCAF Histone Acetyltransferase
Stability : 6 months
A solution in 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride, 1 mM EDTA, and 20% glycerol
pCAF acetylates specific lysines on the N-terminal tails of Histones H3 & H4 and on the transcriptional activators MyoD, E2F1, and p53. Recently, pCAF was also shown to acetylate PTEN on lysine residues K125 & K128 within the catalytic cleft thus inactivating the enzyme. In many, but not all of these cases, acetylation has been shown to enhance the DNA binding affinity of the affected protein. Although the recombinant HAT proteins will acetylate free histones, nucleosomal acetylation only occurs in the context of the in vivo HAT complex.
Purity : >95%
Storage : -80°C
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