PPARγ LBD (human recombinant)
Stability : 6 months
A solution in 50 mM sodium phosphate, pH 7.2, containing 20% glycerol, 150 mM sodium chloride, and 1 mM DTT
Structurally, PPARγ can be described by two primary domains - a ligand binding domain (LBD) and a DNA binding domain (DBD). Binding of activating ligands to the LBD promotes heterodimerization with retinoic acid-like receptor (RXR) resulting in the regulated expression of target genes, a significant number of which are related to lipid metabolism. Select members of the thiazolidinedione class of PPARγ ligands, which includes rosiglitazone and pioglitazone, are currently used for the treatment of insulin resistance associated with type II diabetes.
Purity : >90%
Storage : -80°C
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