PRMT4 Polyclonal Antibody
Stability : 1 year
100 µg of protein G-purified IgG in 200 µl of PBS containing 0.05% BSA and 0.05% mg/ml sodium azide
WB · Protein arginine methylation is an important post-translational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT4, also known as coactivator-associated arginine methyltransferase-1 (CARM1), belongs to a family of proteins that catalyzes the methylation of arginine residues. The PRMT proteins are recuited by C-terminal activation domain-2 of the steroid receptor coactivator (SRC) GRIP-1, whereas p300 interacts with activation domain-1 in the C-terminus. CARM1 can methylate histone H3 in vitro, and a mutation in the putative S-adenosylmethionine binding domain of CARM1 substantially reduces both methyltransferase and coactivator activities suggesting the coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation.
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