Prostaglandin E Synthase (cytosolic) (human recombinant, inactive protein)
Stability : 1 year
Cytosolic prostaglandin E synthase (cPGES) is a glutathione-dependent enzyme with a predicted size of 18.6 kDa. cPGES was first identified as an Hsp90-binding protein and named p23 for the size to which the protein migrated on a SDS-PAGE gel. cPGES is thought to modulate Hsp90 activity during the last stages of the chaperoning pathway. Since its identification as a cochaperone, cPGES was independently cloned, expressed and shown to have PGES activity, catalyzing the isomerization of PGH2 to PGE2. This enzyme is expressed in a variety of tissues and cells and its levels are unaffected by treatment with interleukin-1β and tumor necrosis factor-α. Studies have shown multiple post-translational modifications that affect the activity of the protein.
Purity : 22.3 kDa (His-tagged); 18 kDa (native)
Storage : -80°C
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