Sphingosine Kinase 1 (human recombinant)
Stability : 6 months
10 µg in 25 mM Tris-HCl, pH 8.0, containing 100 mM sodium chloride, 0.05% Tween 20, 50% glycerol, and 3 mM DTT
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date, two isoforms of SPHK, SPHK 1 and SPHK 2, have been identified and characterized from mammalian cells. Among them, SPHK 1 has been implicated to play a role in signalling pathways in mast cells and in TNF-α-triggered responses of fibroblasts and epithelial cells. Recent findings also indicate that SPHK 1 mRNA levels are increased in a variety of human tumors. Brain tumors with high SPHK 1 expression correlated with poor survival of patients and high expression of SPHK 1 appears to be an oncogenic event required for erythroleukaemia progression. Thus SPHK is a potential therapeutic target for the control of cancer and inflammation.
Purity : >80% by SDS-PAGE
Storage : -80°C
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