Sphingosine Kinase 2 (human recombinant)
Stability : 6 months
10 µg in 25 mM Tris-HCl, pH 8.0, 100 mM sodium chloride, 0.05% Tween 20, 50% glycerol, and 3mM DTT
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate sphingolipid D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date, two isoforms of SPHK, SPHK 1 and SPHK 2, have been identified and characterized from mammalian cells. SKs, through the formation of S1P, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis, and vascular maturation. Thus SPHKs are potential therapeutic targets for the control of cancer, inflammation, and other diseases.
Purity : >80% by SDS-PAGE
Storage : -80°C
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