BACE Inhibitor Screening Assay Kit

Synonyms : β-Secretase Inhibitor Screening Assay Kit
Stability : 6 months
Description :
BACE has been shown to be the major β-secretase and a promising therapeutic target as this protease initiates the first step in Aβ production. Inhibition of BACE activity could potentially block the entire cascade of Alzheimer’s disease pathogenesis. In addition, BACE deficient mice do not generate Aβ peptide. In transgenic murine models of AD driven by Aβ overproduction, BACE deficiency rescued memory deficits and cholinergic dysfunction. Additionally, the fact that β-secretase is an aspartic protease has also raised the hope that its therapeutic inhibitor can be as successful as that against HIV protease.After cleavage by BACE, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using a fluorescence plate reader or a fluorometer with excitation wavelengths of 335-345 nm and emission wavelengths of 485-510 nm.
Storage : -80°C