What is Indapamide?

  Indapamide is a thiazide-like diuretic biologic marketed by Servier, about acclimated in the analysis of hypertension, as able-bodied as decompensated affection failure. Combination affairs with perindopril (an ACE inhibitor antihypertensive) are aswell available.

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Nonoxinol Uses

  Nonoxynols aswell accepted as nonaethylene glycol or polyethylene glycol nonyl phenyl ether are mixtures of nonionic surfactants acclimated as detergents, emulsifiers, wetting agents or defoaming agents. The a lot of frequently discussed admixture nonoxynol-9 is a spermicide, formulated primarily as a basic of vaginal foams and creams. Nonoxinol was begin to metabolize into chargeless nonylphenol if administered to lab animals. Arkopal-N60, with on boilerplate 6 ethylene glycol units is a accompanying acclimated surfactant.

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  Nonoxinol, the alive additive of abounding spermicide foams and creams, has been apparent to inactivate finer top titres of HIV in vitro. Therefore the aboriginal administering of nonoxinol, conceivably by a abduction victim herself, has been appropriate as a abeyant antibacterial assay for blockage of a accessible HIV infection. For argumentative DNA character testing, it becomes pertinent to actuate whether nonoxinol could accept an adverse aftereffect on the accretion of top atomic weight DNA from postcoital vaginal swabs and thereby accept an appulse on brake fragment breadth polymorphism (RFLP) analysis.

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  Magnesium isoglycyrrhizinate (MgIg) has been abundantly acclimated in alleviative alarmist abrasion which is the accepted adverse acknowledgment of docetaxel (DOC). Due to the attenuated ameliorative window, baby changes in pharmacokinetic profiles can adapt the toxicity and ameliorative ability of DOC significantly. The abstraction aimed to analyze the furnishings of Magnesium isoglycyrrhizinate on the disposition of DOC and the abeyant apparatus in DOC-induced alarmist injury.

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What is Rubitecan?

  The only approved camptothecins for use in patients to date (topotecan and irinotecan) are delivered intravenously. Thus, an oral camptothecin analogue that would provide the convenience of oral delivery with the flexibility for a variety of prolonged treatment schedules would be advantageous. Rubitecan is an orally available camptothecin analogue that also has potential for delivery transdermally or by inhalation. Like all of the camptothecins, its antitumour activity is mediated through the inhibition of DNA topoisomerase I, which is involved in relaxing supercoiled DNA, which is important for the process of DNA replication and RNA transcription. Rubitecan exists in equilibrium as 9-nitro-camptothecin (9-NC) and 9-amino-camptothecin (9-AC), a metabolite that is thought to be active although it failed in clinical trials. Both 9-NC and 9-AC contain a lactone ring that is required for optimal activity with the carboxylic acid (open ring) forms being significantly less active or inactive.

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  Pranlukast is a cysteinyl leukotriene receptor adversary that has been acclimated to amusement bronchial asthma and allergic rhinitis. In vitro abstracts advance that pranlukast is a substrate of CYP3A4. Thus, the aftereffect of clarithromycin, a almighty CYP3A4 inhibitor, on the pharmacokinetics of pranlukast was advised in an open-label, randomized, two-way crossover abstraction in 16 advantageous macho volunteers.

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Indapamide: a different diuretic?

  Indapamide (Lozol) is a new diuretic and antihypertensive agent. The biologic appears to accept a different apparatus of action, accumulation diuretic furnishings with a absolute vascular action, apparently accessory to calcium approach blockade.

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Health benefits of Nymphaea coerulea extract

  Nymphaea coerulea extract, bigger accepted as the dejected lotus flower, is in fact a allowance to the world. Originally begin on the banks of the river Nile, the Nymphaea coerulea extract, aswell alleged the dejected lily, today is begin all over the apple including the Indian sub-continent. This admirable dejected annual is advised angelic by Indians, abnormally the Buddhists.

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  The recommended dosage of prostaglandin E1 as analysis for arrect dysfunction has been appear to be 10 to 40 micrograms. However, adverse furnishings apparently access with accretion doses. We conducted a prospective, single-blind, dose-escalating abstraction of prostaglandin E1 on 20 men with arrect dysfunction of assorted etiologies.

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Pharmacology of flibanserin

  Flibanserin has best affection for serotonin 5-HT(1A), dopamine D(4k), and serotonin 5-HT(2A) receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5-HT(1A) agonist, a actual anemic fractional agonist on dopamine D(4) receptors, and a 5-HT(2A) antagonist. In vivo flibanserin binds appropriately to 5-HT(1A) and 5-HT(2A) receptors. However, beneath college levels of academician 5-HT (i.e., beneath stress), flibanserin may absorb 5-HT(2A) receptors in college admeasurement than 5-HT(1A) receptors. The furnishings of flibanserin on adenylyl cyclase are altered from those of buspirone and 8-OH-DPAT, two added declared 5-HT(1A) receptor agonists.

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