Cysteinyl Leukotriene EIA Kit

Synonyms : CysLT ELISA Kit
Stability : 6 months
Description :
The leukotrienes (LTs) were discovered in 1979 as a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. Their biosynthesis was shown to proceed via the 5-lipoxygenase (5-LO) pathway. LT biosynthesis has subsequently been demonstrated in other bone marrow-derived cells expressing 5-LO including eosinophils, mast cells, and macrophages. 5-LO converts arachidonic acid into LTA4 with 5(S)-HpETE as an intermediate. The conjugation of glutathione to LTA4 results in the formation of LTC4. LTC4 is rapidly metabolized to LTD4 and LTE4. This metabolism is essentially complete within 10 minutes in the human lung. LTC4, LTD4, and LTE4 are collectively referred to as cysteinyl-leukotrienes (cysLTs). LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE4 is much lower in most systems studied, but its presence reflects the prior existence of LTC4 and LTD4.
Specificity :
Leukotriene C4 100% 
Leukotriene D4 100% 
Leukotriene E4 79%
Storage : -80°C