DNA Methylation EIA Kit (Solid Plate)

Synonyms : 5-Methyl-2'-deoxycytidine ELISA Kit
Stability : 1 year
Description :
DNA methylation is an important epigenetic process regulating gene expression. Methylation occurs on carbon 5 of 2-deoxy cytidine yielding the modified base 5-methyl-2-deoxy cytidine. The methylation pattern of cells is tightly regulated during development with the methylation profile being transmitted from parent to daughter cells during cell division. Methylation results in long-term silencing of genes, while unmethylated regions of DNA can be actively transcribed.1,2 One region of the genome of particular interest in regard to methylation is CpG islands. CpG islands are regions approximately 200 bp to several thousand bp in length which often span the promoter and first few exons of many housekeeping and tumor suppressor genes. These regions remain essentially unmethylated throughout development. As the name implies, the CpG dinucleotide is overrepresented in CpG islands, with the frequency being approximately five times greater in CpG islands than in the remainder of the genome. It is well established that alterations in DNA methylation are a common feature of cancer.
Specificity :
5-methyl-2'-deoxy Cytidine 100% 
5-methyl-Cytidine 20% 
2-deoxy-Cytidine 0.1%
Storage : -20°C