Leukotriene B4 EIA Kit

Synonyms : LTB4 ELISA Kit
Stability : 6 months
Description:LTB4 has long been recognized as a potent mediator of inflammation. It stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human PMNLs. At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production. Plasma levels of LTB4 increase from <100 pg/ml to >100 ng/ml following leukocyte stimulation. LTB4 is metabolized in leukocytes and hepatocytes to less active 20-hydroxy and 20-carboxy LTB4 by NADPH-dependent cytochrome P450 enzymes followed by β-oxidation at the ω-end to ω-carboxy dinor LTB4 and ω-carboxy tetranor LTB3. LTB4 is not excreted in the urine.
Specificity :
Leukotriene B4 100% 
5(S)-HETE 6.6% 
5(R)-HETE 3.7%
Storage : -20°C