Leukotriene C4 EIA Kit

Synonyms : LTC4 ELISA Kit
Stability : 6 months
Description :
LTC4 is rapidly metabolized to LTD4 and LTE4 as shown in Figure 1 (see below). This metabolism is essentially complete within 10 minutes in the human lung. LTC4, LTD4, and LTE4 are collectively referred to as cysteinyl-leukotrienes (cys-LTs). LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Cys-LTs can accumulate to relatively high concentrations in the effusion fluids associated with inflammation (e.g., ascities fluid, synovial fluid, pleural effusion, pericardial or cerebral aspirates). Since LT metabolism is incomplete in these circumstances, substantial amounts of LTC4, LTD4, and LTE4 may be present (e.g., bronchalveolar lavage fluid from asthmatic subjects may contain 700-1,000 pg/ml of cys-LTs comprised mainly of LTC4 and LTD4). Cys-LTs are excreted in urine as intact LTE4 (~9-12%) and LTE4 metabolites. Since LTC4 and LTD4 and virtually absent from urine, the cys-LT measurement in urine is often best accomplished by measuring LTE4 (LTE4 EIA Kit, Catalog No. 520411). Cultured cells synthesizing LTC4 will generally release it into the medium where it will accumulate without further metabolism.
Specificity :
Leukotriene C4 100% 
Leukotriene C5 100% 
Leukotriene D5 48%
Storage : -80°C