Prostaglandin D Synthase Inhibitor Screening Assay Kit

Stability:6 months
storage:-80°C
Description:Prostaglandin D2 (PGD2) is synthesized by two distinct types of prostaglandin D synthase (PGDS), the lipocalin-type (L-PGDS) enzyme and the hematopoietic (H-PGDS) enzyme. PGD2 is produced by H-PGDS in large quantities by allergen-stimulated mast cells and acts as a pro-inflammatory mediator in allergic reactions. Selective inhibition of H-PGDS is therefore being pursued as a drug target for allergy treatment. The Chemical PGDS Inhibitor Screening Assay Kit is a complete package for the evaluation of PGDS isozyme-specific inhibitors. Each kit includes highly purified H-PGDS and L-PGDS, as well as PGH2 which serves as the enzyme substrate. A complete enzyme immunoassay (EIA) for the direct quantification of PGD2 quantification without prior methoximation is included in the kit.