Prostaglandin D2 FPIA Kit - Red

Synonyms : PGD2 Fluorescence Polarization Immunoassay - Red
Stability : 6 months
Description : 
Prostaglandin D2 (PGD2) is biosynthesized in the brain by a soluble, 26 kD glutathione-independent lipocalin-type PGD2 synthase (L-PGDS).1 PGD2 accumulates in the cerebrospinal fluid (CSF), where it induces physiologic sleep in rats and humans.2 PGD2 is also synthesized by mast cells and leukocytes by a cellular, myeloid-type, glutathione-dependent PGD synthase (hematopoietic PGD Synthase; H-PGDS). This PGD2 which is formed in the intracellular and vascular compartments is rapidly metabolized to 11β-PGF2α. Thus, urinary measurements of PGD synthesis are most appropriately focused on the measurement of 11β-PGF2α. Measurement of the parent eicosanoid PGD2 is appropriate in the supernatants of cell cultures, where PGD2 levels may reach several ng/ml, and in CSF, where concentrations of several hundred pg/ml have been measured.
Specificity :
Prostaglandin F2α 118.46% 
Prostaglandin D2 100% 
Prostaglandin J2 24.40%
storage : -80°C