Thromboxane B2 EIA Kit

Synonyms : TXB2 ELISA Kit
Stability : 1 year
Description :
Thromboxane A2 (TXA2) is produced from arachidonic acid by many cells and causes irreversible platelet aggregation and vascular and bronchial smooth muscle contraction. TXA2, like most lipid mediators, is not a circulating hormone. It is formed in response to local stimuli and exerts its effects within a short distance of its biosynthesis. TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2, which is then quickly metabolized (t½ = 5-7 minutes) to urinary metabolites for clearance by the kidneys. Because of the transient nature of this compound it is difficult to accurately measure circulating levels in whole-animal experimental models. In fact, it has been shown that plasma and urine levels of TXB2 are primarily due to ex vivo platelet activation and intra-renal production, respectively. Therefore, measurement of TXB2 metabolites such as 11-dehydro TXB2 (Catalog No. 519501) and 2,3-dinor TXB2 (Catalog No. 519051) in urine and plasma may give better estimates of in vivo TXA2 production. TXB2 measurement is better suited towards samples that are not expected to undergo extensive metabolism such as perfusates, lavage samples, tissue/cell culture, etc.
Specificity :
Thromboxane B2 100% 
Thromboxane B3 200% 
2,3-dinor Thromboxane B2 9.9%
Storage : -20°C