Calcium D-glucarate Interactions with Hormones

Steroid Hormones

In rats given 10% of the diet as calcium-D-glucarate, serum estrogen has been noted to be reduced 23% comparative to control. Although 10% of the diet is approximately 1, 000mg/kg (estimated human equal based when body weight conversions), 200mg/kg should be somewhat similarly effective (see dosing section).

Although no correctly directly investigated the excretion of testosterone, it is recognized to be glucuronidated and inhibition of glucuronidation is a mechanism by which eco-friendly tea catechins are believed to increase testosterone in the body; it is wholly plausible that serum testosterone is reduced following glucaric acid supplementation, but currently not exhibited.

Furthermore, urinary 17-ketosteroids (collective term for DHEA, androstenedione, androsterone, and estrone) seem to be increased roughly 200% following 2 times over a diet containing 10% calcium-D-glucarate in rats but is attenuated to fifty percent after two weeks.

Urinary: excretion of all steroid hormones appears to be increased following exposure to D-glucaric acid at high mouth doses since these anabolic steroid hormones themselves are an issue to glucuronidation