Decapeptide 12 Does Help Skin-Brightening

As we all know, peptide synthesis has been often used in cosmetics in the past few years. Among various peptides, Decapeptide synthesis is quite popular, especially Decapeptide 12.     

Decapeptide 12 structure

Lumixyl is a cosmetic material that inhibits melanin formation, diminishes pigmentation, reduces pigmentation, and evens and brightens skin. Developed by Stanford University dermatologists, it is the only novel peptide proved to effectively inhibit tyrosinase in the skin.   (tyrosinase promotes excessive production of melanin, resulting in uneven pigmentation and dark spots).

Whether people's skin is white or not mainly depends on the ability of melanocytes to synthesize melanin. In the basal cells of the human epidermis, melanocytes are distributed which contain tyrosinase to oxidize tyrosine into polysaccharides, and then undergo a series of metabolic processes to produce melanin. The more melanin is produced, the darker the skin is; on the contrary, the more white the skin becomes. Due to the decapeptide mechanism of action, it is a potential raw material for cosmetics.

Decapeptide 12 Why can it help skin whitening?

Tyrosinase has a unique dual catalytic function and is a key enzyme in melanin synthesis in vivo, which is closely related to human aging. Abnormal overexpression can lead to pigmentation diseases in the human body. Tyrosinase inhibitors can treat the currently common pigmented skin diseases such as freckles, chloasma, and senile plaques. Among the popular whitening cosmetics on the market, arbutin, vitamin C derivatives, kojic acid and its derivatives, green tea extract, licorice extract, and other traditional Chinese medicine extracts are all tyrosinase inhibitors, mainly by inhibiting the ability of tyrosinase to inhibit the synthesis of melanin, thereby exerting a whitening effect. 

Tyrosinase is the enzyme that catalyzes the first two steps (and possibly the fifth) of the biochemical synthesis of melanin. Some researchers showed that decapeptide 12 was nearly a 17-fold more potent tyrosinase inhibitor than hydroquinone and that unlike hydroquinone, it did not cause melanocyte cytotoxicity. A small pilot clinical study further demonstrated that 0.01% decapeptide 12, formulated in an inert cream base, diminished the appearance of recalcitrant melasma by 40% and 50% after 12 and 16 weeks of twice-daily application, respectively.

Decapeptide 12 inhibits tyrosinase synthesis, thereby effectively (40%) reducing melanin production. It can maximally dilute chloasma, freckles, age spots, sun spots, uneven skin tone and light injury caused by excessive pigmentation. And Lumixyl Decapeptide 12 has no hydroquinone toxicity and side-effects which some other whitening ingredients have, such as allergies, irritation, and redness.

Study on the effect of Decapeptide 12 on skin

A prospective study was done to evaluate the safety and efficacy of decapeptide 12 in conjunction with an antioxidant cleanser, glycolic-acid containing facial moisturizer and broad-spectrum sunscreen to treat facial hyperpigmentation associated with chronic photodamage. When the study was finished, all study-related treatments were well tolerated. The mechanism of action of decapeptide 12 includes inhibition of melanin synthesis via inhibition of the tyrosinase enzyme. Advantages of decapeptide 12 over other skin-brightening agents include its low incidence of side effects, lack of cytotoxicity and safe use in ethnic skin as well as in patients who have failed other treatment regimens.

A patient was beset by melanin, she almost gave up after using a large number of cosmetics. Luckily, she tried cosmetics containing decapeptide-12 which helped her a lot. Her successful medical experience is as follows. 
She was treated with a series of medical procedures spaced 2 weeks apart. Each treatment infused a solution containing 0.01% decapeptide-12. During the treatment, the patient was instructed to wear daily sunscreen (SPF30 or higher) and to apply a cream containing 0.01% decapeptide-12 (Lumixyl cream) twice daily. Dermalinfusion of decapeptide-12 (Lumixyl) combined with a twice-daily application of a decapeptide 12 cream can safely and effectively be used to accelerate clearance of PIH in the skin of color. After several months’ treatment, her facial disease was improved a lot. 

Where to buy Decapeptide 12

Our company offers bulk Decapeptide 12, please contact us if you need to purchase, or go to this page to view the product details.

Reference

http://jddonline.com/articles/dermatology/S1545961614P0084X/1
https://www.ncbi.nlm.nih.gov/pubmed/22401652